A Study on Genetic Toxicity of Formaldehyde
- VernacularTitle:甲醛诱导小鼠骨髓细胞微核和DNA损伤的研究
- Author:
Fen RONG
;
Fusheng YUAN
;
Wuhong ZHAO
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
DNA damage;
Micronuclei test;
Single cell gel electrophoresis
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the genotoxicity of formaldehyde to mice.Methods Mice were exposed to formaldehyde of several concentrations(1.25,0.50,and 5.00 mg/m3) in the toxicant exposure chamber,2 h/d for 15 consecutive days.Bone marrow micronuclei test and single cell gel electrophoresis were employed to test the genotoxicity.Results Compared with the control group,a significant increase in the rate of micronuclei and the DNA damage of peripheral lymphocytes in experimental groups were found.As to the rate of micronuclei and DNA damage,an obvious dose-effect relationship was showed.Conclusion Formaldehyde has a genotoxic effect for mice,much more attention should be paid in this research field.
