Effect of Nonylphenol on the Fertility of Mice
- VernacularTitle:壬基酚对小鼠生育力的影响研究
- Author:
Lijie YE
;
Haishan LI
;
Yumin ZHANG
- Publication Type:Journal Article
- Keywords:
Fertility;
Nonylphenol;
Reproductive toxicity;
Developmental toxicity
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of nonylphenol (NP) on the fertility of mice,and assess its reproductive and developmental toxicity.Methods 128 mature KM mice weighed 22-26 g were randomly divided into three experimental groups (24,60 and 120 mg nonylphenol/kg bw respectively) and the control group (earthnut oil ),16 in each.Fertility tests were performed according to the procedure commended by EPA.Results Sperm number,sperm vitality,fertility index and pregnancy rate decreased,while rate of deformed sperm increased in dose-dependent manner at dose of 60 and 120 mg/kg bw (P
