DNA Damage in Mice Testicle Cells Induced by Organic Extracts of Fishpond Water Containing Sewage
- VernacularTitle:养殖污水有机提取物对小鼠睾丸细胞的DNA损伤作用
- Author:
Zengrong SUN
;
Xuehui LIU
;
Yan LU
- Publication Type:Journal Article
- Keywords:
Water pollution;
DNA damage;
Comet assay
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the genotoxicity of organic extracts (OEs) of fishpond water containing sewage.Methods Male Kunming mice were randomly divided into different groups according to the body weight,6 in each group.The OEs were administrated to the mice through peritoneal injection at the doses of 25.00 L/kg,12.50 L/kg and 6.25 L/kg respectively for 3 consecutive days.The negative and positive control groups were treated with DMSO and cyclophosphamide (CP) respectively.The DNA damage was tested by using un-fluorescent staining comet assay.Results The tailed-cells rates and tail length in each OEs treated group were significantly higher than those in the negative control group (P
