Effect of Omethoate on DNA in Mice Testicle Cells
- VernacularTitle:氧化乐果对小鼠睾丸细胞DNA的损伤
- Author:
Bo ZHANG
;
Limeng ZHU
- Publication Type:Journal Article
- Keywords:
DNA damage;
Pesticide;
Omethoate;
Single cell gel electrophoresiss
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the adverse effect of omethoate on DNA in mice testicle cells in vivo.Methods 24 mice were randomly divided to 4 groups:control(no omethoate),1,2 and 4 mg/kg.omethoate was given by gavage one time a day for consecutive 7 days.DNA damage was detected by single cell gel electrophoresiss (SCGE).Results At the concentration of 1,2,4 mg/kg,omethoate induced DNA damage in mice testicle cells in vivo with an obvious dose-effect relationship(r=0.969 5).Conclusion Omethoate may cause DNA damage in mice testicle cells.
