Effect of Alcohol on Apoptosis and Expression of Bcl-2 and Bax Genes of Myocardial Cells of Mice
- VernacularTitle:乙醇对心肌细胞凋亡及凋亡相关基因Bcl-2和Bax表达的影响
- Author:
Xiangmin YU
;
Min JIANG
- Publication Type:Journal Article
- Keywords:
Alcohol;
Myocardium;
Apoptosis;
B-cell lymphoma/leukemia-2;
Bcl-associated x protein
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of alcohol on apoptosis and apoptosis-associated genes-Bcl-2 and Bax of cardiac muscle cell.Methods We established an animal experimental model by giving different concentration of alcohol to the healthy mice.Myocardial apoptosis and the expression of apoptosis-associated gene Bcl-2 and Bax were quantitatively analysed by the nuclear fast red-crystal violet staining and immunohistochemical method.Results Some nuclears of the experimental groups were stained purple and agglutinated.Counting under the high power microscope,it was found that the amount of abnormal nuclears significantly increased in alcohol-treated groups compared with the control group (P
