Effects of non-wounded ischemic preconditioning on lung ischemia/reperfusion induced lipid peroxidation
- VernacularTitle:非创伤性缺血预处理对肺缺血-再灌注损伤的保护作用
- Author:
Sheyhidin ILYAR
;
Dongbo LUO
;
Chunsheng LIU
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning;
Reperfusion injury;
Lung;
Lipid peroxidation
- From:
Chinese Journal of Organ Transplantation
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of non-wounded ischemic preconditioning (N-WIP) on lung ischemia/reperfusion (I/R) injury.Methods Two animal models with N-WIP and the classical ischemic preconditioning respectively were used. Forty New Zealand White rabbits were randomly divided into 4 groups, each group having 10 animals: control group (C), ischemia/reperfusion group (I/R), classical ischemic preconditioning group (C-IP), and N-WIP group. Lung injury was assessed by arterial oxygen tension (PaO2), wet to dry weight ratio (W/D), activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and level of malondialdehyde (MDA).Results In I/R group, PaO2 was descended constantly, especially within 30 min after reperfusion. PaO2 and the activities of SOD, GSH-PX in serum and lung tissue in N-WIP group and C-IP group were both significantly higher than those in I/R group (P
