Reorientation of T cell receptors during immunological synapse formation:a vortex-driven model
- VernacularTitle:免疫突触形成过程中T细胞受体的重定向运动:涡旋驱动模型
- Author:
Shunhui LIU
;
Boping HAN
;
Yaoying ZENG
;
Xianhui HE
- Publication Type:Journal Article
- Keywords:
Immunological synapse;
T cell receptor;
Reorientation movement;
Vortex
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop the mechanistic model for the reorientation of T cell receptors during immunological synapse formation.Methods:Based on the theory of energy transfer during double-molecular reactions in the context of classical fluid mechanics,a vortex-driven model was proposed where in the coupled receptor/ligand molecules within the immunological synapse recruit the T cell receptors.Results:The model results indicated that driven by the consecutive vortexes with specific combinations of strengths and acting frequencies of vortexes,TCR transport speed can reach the values matching up to the experimental measurements(0.04-0.1 ?m/s).Conclusion:The model demonstrated that during the coupling,the membrane-tethered receptor-ligand pairs may transform their binding energies into the rotational energies of the reactants,thereby leading to the vortexes of the surrounding water continuum insider and outside the T cell,and these resulting vortexes may function as the engines for the reorientation of T cell receptors.
