Antitumor effect of H22 cells transfected with B7-1 in mice
- VernacularTitle:B7-1基因转染小鼠肝癌细胞诱导的抗瘤效应研究
- Author:
Quan WANG
;
Jian SUO
;
Hongjuan JIN
;
Jingqi XIAO
- Publication Type:Journal Article
- Keywords:
Costimulatory molecule;
H22 cells;
Gene transfection
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of B7-1 costimulatory molecule in inducing tumor immunity.Methods:The lymphocytes were examined in vitro,for both proliferation induces(PI) and specific cytotoxic activity,H22 mice were challenged subcutaneously either by the mock following which the latency,survival time and tumor mass growth were noted.Results:The H22-B7-1 cells more effectively induced the proliferation of effecter lymphocytes and the generation of specific lytic activity against H22 cells.The H22-B7-1 cells demonstrated slower rate(P
