Mutations in the D-loop region of mitochondrial DNA in gastric cancer
- VernacularTitle:胃癌线粒体DNAD-loop区突变的检测和分析
- Author:
Zhuanglei GAO
;
Zongli ZHANG
;
Shuping LIU
;
We WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms?DNA,mitochondria?Gene conversio n?Polymorphism
- From:Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the variations o f mitochondrial D-loop region in gastric cancers. Methods:The D-loop region of 12 gastric cancers together with th e adjacent normal tissues were amplified by PCR and sequenced. Results: Among the 12 cases,16 mutations and 28 polymorphisms were identified with the mutations rate of 50%.There were 3 new polymophisms which we re not reported previously in the GeneBank among the 28 polymorphisms. Conclusion:We think that the mitochondrial DNA D-loop region is a highly polymorphric and mutable region and the mutation rate is relatively high in patients with gastric cancer.
