Effects of MAPK on a human inflammatory breast carcinoma cell line
- VernacularTitle:MAPK信号传导通路对人炎性乳腺癌细胞系侵袭能力的影响
- Author:
Huiming DONG
;
Gang LIU
;
Jiong WU
- Publication Type:Journal Article
- Keywords:
cadherin;
kinase;
invasion;
breast neoplasm;
cultured tumor cells
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To invastigate the changes of the related signaling pathways and it's mechanism of reguation of mitogen activated protein kinase cascade(MAPK) by SUM149 cells induced plasmid of dominant-negative E-cadherin mutant H-2k~d-E-cadherin.Methods:Using western blot method,we examined the signal pathway of mitogen activated protein kinase(MAPK) between the dominant-negative mutant E-cadherin transfected SUM149 cells and controls.Results:Compared with the controls,the phosphorylated extracellular signal regulated kinase P44/42 expresion of the SUM149 cells which expressed higher dominant-negative mutant E-cadherin was significantly down-regulated.Conclusions:In this cell line model,the down-regulation of P44/42 may involve the regulation of MMPs.
