Relationship of oncogene survivin、c-erbB-2 expression in breast cancer and its prognostic significance
- VernacularTitle:乳腺癌组织中survivin、c-erbB-2基因的表达与预后的关系
- Author:
Jie MAO
;
Jian HAI
;
Hengping SHU
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
survivin;
c-erbB-2;
prognosis;
immunohistochemistry
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the expression of oncogene survivin,c-erbB-2 in breast cancer and its prognostic significance.Methods:Detect the expression of survivin,c-erbB-2 in 80 case breast cancer tissues by immunohistochemistry S-P method,analyze its correlation with axillary lymph node metastasis and 5-year disease free survival(DFS).Results:Survivin gene positive expression rate was 68.75%(55/80),c-erbB-2 gene positive expression rate was 36.25%(29/80) in breast cancer tissues,all have positive correlation with the axillary lymph nodes metastasis but negative to 5 years DFS(P0.05);survivin and c-erbB-2 genes expression have positive correlation(P
