Effect of all-trans retinoic acid on the excretion of urine TGF ?_1 and glomerular lesion of diabetic rat
- VernacularTitle:全反式维甲酸对糖尿病大鼠尿转化生长因子-?_1排泄率及肾小球病变的影响
- Author:
Dan ZHU
;
Baosong GUI
;
Ganglian YAO
;
Dengfeng GAO
;
Ning NING
;
Hongli ZHANG
- Publication Type:Journal Article
- Keywords:
all-trans-retinoic(atRA);
diabetic nephropathy;
transforming growth factor-?_1(TGF?_1);
rat;
streptozotocin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of all-trans retinoic acid(atRA) on the urinary TGF?_1 excretion and glomerular lesion of diabetic rats at early stage.Methods SD rats were randomly assigned into 3 groups: atRA treated group,diabetic control group and normal control group.Streptozotocin(STZ)-induced early diabetic male SD rat were used.The atRA treated group were treated with daily subcutaneous injections atRA of 10mg/kg for 7 days(n=6),and then the excretion of urinary protein and TGF?_1 and NO level of plasma,urine and renal tissue were measured,and pathological changes of their kidneys were observed.Results The diabetic control rats showed increased urinary excretion of protein and TGF?_1 and NO level of plasma,urine and renal tissue and deposit of glomerular matrix,while atRA prevented these changes.Conclusion AtRA can prevent the development of diabetic nephropathy,which is relevant with the inhibition of secretion of TGF?_1 and NO.
