Experimental study of the effect of asiaticoside on preventing restenosis after percutaneous coronary intervention
- VernacularTitle:积雪草甙防治PCI术后再狭窄的实验研究
- Author:
Jianxie ZHOU
;
Hongwei JIANG
;
Lei YI
;
Qiang LUO
;
Wensheng LI
;
Kezhen WANG
- Publication Type:Journal Article
- Keywords:
PCI;
restenosis;
endothelial cell;
asiaticoside;
endothelin;
nitric oxide
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of asiaticoside in preventing restenosis after percutaneous coronary intervention(PCI).Methods The rabbits' model of iliac arterial balloon injury was established and treated with asiaticoside for 4 weeks.The level of serum endothelin(ET),nitric oxide(NO) and C-reactive protein(CRP) was measured respectively and the pathological characteristics of iliac artery of rabbits were observed under light microscope.Results The serum ET and CRP obviously increased and the serum NO significantly decreased after the rabbits' iliac artery was peeled off by balloon injury(Compared~()with the control group,P
