Relationship between preoperative staging of endoscopic ultrasonography and genic expression of MMP-9 in gastric carcinoma
- VernacularTitle:胃癌内镜超声分期与MMP-9基因表达的关系
- Author:
Shiyun TAN
;
Lei SHEN
;
Hesheng LUO
;
Zhixiang SHEN
- Publication Type:Journal Article
- Keywords:
Endosonography;
Stomach neoplasms;
Neoplasm staging;
Matrix metalloproteinase 9
- From:
Chinese Journal of Ultrasonography
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the staging of endoscopic ultrasonography(EUS) and the expression of carcinoma metastasis associated genic in the patients with gastric carcinoma.Methods Sixty-three patients with gastric cancer were diagnosed by electric gastroscopy and EUS.The preoperative staging of gastric cancer was measured by EUS and compared by pathologic staging and MMP-9 expression.MMP9 level of peripheral serum was measured by enzyme-linked immunosorbent assay,while the expression of MMP-9 protein was tested by immunohistochemistry and hybridization in situ in the gastric carcinoma tissue.Results The total accuracy rate of EUS in estimating invasive depth of gastric cancer was(80.95)%,while that of lymphatic metastasis was(73.02)%.The expression level of MMP-9 in serum was consistent with the expression of MMP-9 protein and MMP-9 mRNA in tissue,which was closely correlative with invasive degree,staging with EUS,lymphatic metastasis in gastric cancer(P
