Effect of adrenomedullin on insulin sensitivity in normal Wistar rats
- VernacularTitle:肾上腺髓质素对正常Wistar大鼠胰岛素敏感性的影响
- Author:
Huaqi LI
;
Nanwei TONG
- Publication Type:Journal Article
- Keywords:
Adrenomedullin;
Insulin sensitivity;
Hyperinsulinedmic-euglycemic clamp
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of adrenomedullin (AM) on insulin sensitivity in normal Wistar rats was investigated by hyperinsulinemic-euglycemic clamp in combination with isotope dilution technique. The infusion rates of AM during the clamp were 0, 0.05, 0.2, 1 ?g?kg~(-1)?min~(-1), rspectively. The glucose disposal rate (GDR) and hepatic glucose output (HGO) were calculated by the plasma 3-~(3)H-glucose specific activity. After AM infusion, the insulin-mediated glucose disposal was reduced in a dose-dependant manner. It indicated that high dose of AM could induce a marked state of insulin resistance, which was mainly characterized by inhibition of the effect of insulin to stimulate peripheral glucose metabolism.
