Progress in free fatty acid receptor GPR40
- VernacularTitle:脂肪酸受体GPR40研究进展
- Author:
Feng ZHU
;
Hong LI
- Publication Type:Journal Article
- Keywords:
G protein-coupled receptor;
Fatty acids;
Hyperplasia;
Islet ?-cells
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The G protein-coupled receptor, GPR40, is a specific receptor for free fatty acids. Singnaling pathways are activated in islet ?-cells by fatty acids as binding to GPR40. Fatty acids regulate insulin secretion and cause ?-cell hyperplasia through GPR40. GPR40 also mediates responses to antidiabetic drugs like thiazolidinediones. GPR40 agonists and/or antagonists show potential effect in the development of new anti-diabetic drugs.
