Expression and significance of hTERT,p16 and Topo-Ⅱa in astrocytoma by tissue microarray
- VernacularTitle:利用组织芯片研究星形细胞瘤中端粒酶hTERT,p16及Topo-Ⅱa的表达及意义
- Author:
Qinghua LIU
;
Jinfen WANG
;
Lingmin LI
- Publication Type:Journal Article
- Keywords:
Astrocytoma;
hTERT;
p16;
Topo-Ⅱa;
Tissue microarray;
Immunohistochemistry
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression of hTERT, p16 and Topo-Ⅱ? in astrocytoma as well as their relationship during histogenesis and development of astrocytoma. Methods The expression of hTERT, p16 and Topo-Ⅱa in 64 astrocytoma specimens with different malignant grades and 10 normal brain tissues were studied using tissue microarray and immunohistochemistory. Results The expression rate of hTERT and Topo-Ⅱa were 50 % and 59.4 % respectively, they increased along with the increase of the malignant grade(P
