Cytokine influence on thyrocytes apoptosis and related protein expression in patients with Graves' disease
- VernacularTitle:细胞因子对Graves病甲状腺细胞凋亡及相关蛋白表达的影响
- Author:
Fengping HE
;
Shan LI
;
Su XIAN
;
Hanlei SHEN
;
Yunfei LU
;
Ruixing YIN
- Publication Type:Journal Article
- Keywords:
Graves disease;
Cytokine;
Apoptosis
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate cytokine(TNF-?,IL-1) effect on apoptosis and express of related protein in thyrocytes and the relationship with pathogenesis in Graves' disease(GD).Methods:To test thyroid tissues from 50 patients with GD Fas expression by immunohistochemical method.Thyroid tissues were collected from samples of GD operation and were cultured by primary culture method.Content of sFas in culture medium was tested by ELISA.Fas/sFas mRNA were tested by RT-PCR.Cytokine inducing apoptosis in Graves' disease showes observation group,normal people showes control group.Results:Compare apoptosis culture rate there is significant difference(P
