Correlation of left ventricular geometry with insulin resistance in elderly patients with essential hypertension
- VernacularTitle:老年高血压患者胰岛素抵抗与左室结构改变的关系
- Author:
Qi ZHOU
;
Zhongchao CAO
;
Zigang CHEN
- Publication Type:Journal Article
- Keywords:
Hypertension;
Hyperinsulinemia;
Hypertrophy, left ventricular
- From:
Chinese Journal of Geriatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations between the left ventricular geometry and the insulin resistance (IR) in elderly patients with essential hypertension (EH) and the effect of the IR on the left ventricular geometry. Methods According to left ventricular mass index (LVMI)and relative wall thickness(RWT),72 EH patients were divided into normal geometry group (34 cases ),concentric remodeling group (18 cases ),concentric hypertrophy group (11 cases ),and eccentric hypertrophy group (9 cases ).The oral glucose tolerance test and insulin release test were performed in all patients and 35 healthy subjects as control.The area under curve of glucose tolerance (AG), area under curve of insulin release (AI), fasting serum insulin /fasting serum glucose (FIS/FSG) ratio, AI/AG ratio and insulin sensitivity index (ISI) were calculated.Correlation between RWT,LVMI and 7 insulin-sensitivity parameters were respectively obtained using linear regression analysis,and the stepwise regression analysis was used to assess the independent effect of each parameter. Results RWT was positively correlated with AG、 AI(r=0.160、0.227, respectively, all P0.05). Only ISI was independently correlated with RWT (r2=0.071,P
