Study on abnormality of enzymology and morphology of human detrusor muscle following bladder outlet obstruction
- VernacularTitle:人膀胱出口梗阻后逼尿肌酶学和形态学异常的研究
- Author:
Yi WANG
;
Youcheng XIU
;
Zhenyu ZHANG
;
Wanpeng LIU
;
Guiying GUO
- Publication Type:Journal Article
- Keywords:
Bladder outlet obstruction;
Muscle,smooth/enzymology
- From:
Chinese Journal of Urology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of enzymologic and morphologic changes of the detrusor muscle after bladder outlet obstruction(BOO).Methods The bladder detrusor muscles of 8 cases of BPH with BOO(BOO group) and another 8 cases of bladder tumor without BOO(control group) were collected.The content of MDA and the activity of SOD,NOS and Ca~(2+)Mg~(2+)-ATPase in both groups were measured,and observed under electron microscope.Results The activities of SOD(20.39?2.02)U/mg Protein,NOS(1.81?0.38)U/mg Protein,Ca~(2+)Mg~(2+)ATPase(1.47?0.43)?mol Pi/mg Protein of the detrusor muscles in control group were significantly higher than those of the detrusor muscles in BOO group(12.77?2.62)U/mg Protein,(1.36?0.22)U/mg Protein and(0.97?0.33)?mol Pi/mg Protein;P
