Comparison of Bactericidal Activity in cerebrospinal Fluid of Three Cephalosporins in Patients undergoing Surgery of Skull and Brain
- VernacularTitle:三种头孢菌素在颅脑手术患者脑脊液杀菌效价的比较
- Author:
Rui WANG
- Publication Type:Journal Article
- Keywords:
Ceferiaxone;
Cefotaxcime;
Cefu roxime Bacteriocidal activity in cerebrospinal fluid
- From:
Chinese Journal of Nosocomiology
1994;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The bactericidal activity of serum and cere brospinal fluid (SBA and CBA)of ceftroiaxone (CTRX), cefotaxime(CTX) cefuroxime(CFR) in the patients undergoing surgery of skull and brain were studied by means of microdi luted method. The results showed antibacterial activity of CTRX against, enterobactericeae in vitro or in serum and cerebrospinal fluid (CSF) was the highest, it is suggested that the schadule of CTRX per 12hr may be used in prevention and treatment of serious infections after surgery of skull and brain.The bacteria The SBA and CBA of CFR were less ,but its antibacterial spectrum was wide and bactezi cidal activity of CTX against gram positive strains and enterobactericeae in sencm and CSF were higher, CTX may be used in treatment of infections of nervous system caused by mixed bacteria, the cost was lower, so CFR may be selected in the moderate infections. The CBA was a synthesized guide reflexing the antibactieral activity and penetration into barrier, so it is impostand reference to select antibiotics of infection after surgery of skull and brain.
