Oxidative Damage Effect of Particulate Matter (PM_(2.5)) on the Livers, Spleens, Kidneys of Rats
- VernacularTitle:PM_(2.5)对大鼠肝、脾、肾组织的氧化损伤效应
- Author:
Xiaoli LIU
;
Xianqiang SONG
;
Ziqiang MENG
- Publication Type:Journal Article
- Keywords:
Air pollution;
Air particulate matter;
Anti-oxidative enzyme;
Oxidative damage;
Livers;
Spleens;
Kidneys
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of airborne fine particulate matter(PM2.5) on anti-oxidative enzymes activities and lipid peroxidation levels in livers, spleens, and kidneys of rats. Methods 32 male Wistar rats were randomly divided into PM2.5 exposure groups of different concentration (1.5, 7.5, 37.5 mg/kg), exposed by tracheoperfusion and control group treated with physiological saline. Rats were killed 24 h after treatment, and the levels of thiobarbituric acid reactive substance (TBARS), glutathione(GSH) and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) were determined. Results PM2.5 exposure caused significantly decrease of SOD, CAT, GSH-Px, SOD/TBARS in livers and kidneys in a dose-dependent manner compared with control group (P
