Impacts of recipient’s SNP of cytokine and cytokine receptor on the incidence of infection after renal transplantation
- VernacularTitle:肾移植受者的细胞因子及其受体单核苷酸多态性与术后感染的相关性
- Author:
Yifeng GUO
;
Jianming TAN
;
Rongyu LI
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Cytokines;
Receptors,cytokine;
Polymorphism;
Infection
- From:
Chinese Journal of Organ Transplantation
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of renal allograft donor's and recipient’s SNP of recipient cytokine and cytokine receptor on the infection after renal transplantation and to provide some useful information for preventing and managing infection.Methods 129 cases of cadaveric renal allograft recipients were divided into infection group and no infection group. The distribution of 21 polymorphisms in cytokines and cytokine receptors gene were compared between two groups by oligonucleotide array. Previous positive gene polymorphisms were compared between infection group and no infection group. With the help of SPSS 11.5 software, association was assessed using Krusakal Wallis test where appropriate.Results The frequency of gene distribution was significantly different between the infection group and the no infection group as follows: the genotype IL-6R (-183G/A, GG), IL-10 (-824C/T, -597C/A), TNF-? (-308GG, G/A), and the allele IL-10R1 (1112G/A), IL-6R (-183G/A), IL-4R(1902A/G), TNF-? (-308G/A), TGF-?_1 (+869T/C) respectively.Conclusion The susceptibility of infection after renal transplantation may be predicted by the SNP of recipient cytokine and cytokine receptors such as these genotypes IL-6R(-183GG), IL-10(-824CT, -597CA), TNF-?(-308GG), and the allele IL-4R(1902A).
