Expression and significance of programmed death-ligand 1 and programmed death-1 in acute allograft rejection
- VernacularTitle:急性排斥反应时移植肾组织中程序性死亡配体-1及其受体的表达
- Author:
Xiongfei WU
;
Hanlu DING
;
Jianguo ZHANG
- Publication Type:Journal Article
- Keywords:
Graft rejection;
PD-L1;
PD-1;
Kidney transplantation
- From:
Chinese Journal of Organ Transplantation
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of programmed death-ligand 1 (PD-L1) and programmed death-1(PD-1) in the kidney tissue of acute allograft rejection (AR) and the correlation between PD-L1 expression and PD-1 expression and the degree of tubulointerstitial lesions.Methods Immunohistochemistry and in situ hybridization were used to detect the expression of PD-L1 and PD-1 in renal tissue of normal control and AR confirmed by biopsy.Results Both PD-L1 and PD-1 expression were significantly higher in AR than in the normal renal tissue (P
