Changes of IL-1,IL-6,TGF-?,Fas and FasL expressed by Leydig cell in testis infection
- VernacularTitle:睾丸局部感染时Leydig细胞IL-1、IL-6、TGF-?和Fas、FasL转录水平的变化
- Author:
Yingde ZHANG
;
Yebin XI
;
Weiyi LI
;
Guangjie CHEN
;
Baoguo WANG
;
Tianwei SHEN
;
Shisan BAO
- Publication Type:Journal Article
- Keywords:
Leydig cell;
Immune regulation;
IL-1;
IL-6;
TGF-?;
Fas;
FasL
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of immune regulation of the rat Leydig cells in testis infection.Methods:UU was injected into the bladders of rats,which mimics the ascending infection pathway,while using culture medium injection as control.After 1,2,3 w respectively,the rats were sacrificed to observe the pathological alterations in testis by histological examination.Leydig cell were also separated from testis,the comparation of levels of IL-1,IL-6,TGF-?,Fas and FasL mRNA expression among control and UU infected groups was made by RT-PCR.Results:Compared with control,in UU infected group,the levels of IL-1,IL-6,TGF-? increased,the level of Fas decreased,the level of FasL increased.Conclusion:Leydig cell can play the role of immune regulation,with the expressing changes of IL-1,IL-6,TGF-?,Fas and FasL in the infection of testis in rat.
