Effects of lactic acid bacteria on P38 signaling in immune response to dust mite in mite-sensitized mice
- VernacularTitle:乳酸菌对尘螨致哮喘小鼠的免疫调节及对P38通路的影响
- Author:
Baodan YU
;
Li LI
;
Jun XU
- Publication Type:Journal Article
- Keywords:
Lactic acid bacteria;
Asthma;
Immune regulation;
P38
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of lactic acid bacteria on P38 signaling in immune response to dust time in mite-sensitized mice.Methods:40 C57BL/6 mice in Group M,P and C,except for N(saline control),were sensitized and challenged with mite extract.Mice in C and P were simultaneously fed to Lactococcus lactis and Lactobacillus respectively.Total cell count and classification in BALF were done and IL-4 level detected by ELISA.Western blot were performed for detection of P38 signaling from mice's spleen cells stimulated with mite extract.Results:IL-4 level,total cell count and the percentage of eosinophils in BALF were significantly lower in Group C(P
