The relationship of C-reactive protein, adrenomedullin, brain natriuretic peptide and matrix metalloproteinases with congestive heart failure in the elderly patients
- VernacularTitle:老年人心力衰竭与C-反应蛋白肾上腺髓质素脑钠素和基质金属蛋白酶的关系
- Author:
Liyan XIE
;
Yanping WANG
;
Qian FAN
;
Ping LIU
;
Hai DONG
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
C-reactive protein;
Adrenal medulla;
Natriuretic peptide,brain;
Matrix metalloproteinases
- From:
Chinese Journal of Geriatrics
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of the plasma levels of high sensitive C-reactive protein(hs-CRP),adrenomedullin(ADM),brain natriuretic peptide(BNP)and matrix metalloproteinases (MMPs)with severity of heart falure, the left ventricular ejection fraction and the relationship among them in the elderly patients with congestive heart failure(CHF). Methods The blood samples were obtained from 50 patients with congestive heart failure and 24 healthy controls.The plasma level of hs-CRP was measured by immunoturbidometry.The plasma levels of ADM and BNP were determined by radioimmunoassay.The plasma levels of MMP-2 and MMP-9 were measured with ELISA.Left ventricular ejection fraction(LVEF)was measured by echocardiography. Results The plasma levels of hs-CRP, ADM ,BNP and MMP-2,MMP-9 had significantly negative correlation to LVEF(P
