Relationship between expression of PTEN and VEGF and angiogenesis in bladder can cer
- VernacularTitle:PTEN和VEGF的表达与膀胱癌血管生成关系的研究
- Author:
Jianhua ZHANG
;
Weimin YANG
;
Siwei ZHOU
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
PTEN;
VEGF;
Microvess el density
- From:
Chinese Journal of Urology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of expr ession of PTEN and vascular endothelial growth factor (VEGF) with angiogenesis i n bladder cancers. Methods Using immunohistochemical S- P method,the expression of PTEN and VEGF was examined in 62 bladder cancer sampl es and 18 chronic cystitis samples (control group);and the microvessel density ( MVD) was compared among different expression states of PTEN and VEGF in bladder cancer tissues. Results The positive rates of PTEN in bl adder cancer and control groups were 53.2% (33/62) and 100.0% (18/18),respective ly.The difference between the 2 groups was significant ( P
