The protective effect of hyperoxic liquid preconditioning in myocardial ischemia-reperfusion injury in rabbits
- VernacularTitle:高氧液预处理对兔心肌缺血再灌注损伤的保护作用
- Author:
Guixia JING
;
Jian WEN
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
hyperoxic liquid;
ischemic reperfusion injury;
oxygen-derived free radicals
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of hyperoxic liquid preconditioning in myocardial ischemia-reperfusion injury. Methods Thirty rabbits were randomly divided into three groups: group A undergoing all procedures except ischemia-reperfusion, group C receiving the routine infusion of hyperoxic liquid 15mL/kg for seven days, and group B receiving the routine treatment infusion of saline instead of hyperoxic liquid 15mL/kg. Seven days later, the myocardial ischemic reperfusion model (I/R) was fabricated, ECG and homodynamic index were monitored simultaneously. Plasma MDA and SOD level was assayed before ligation, 30min after ligation and 1, 2, 3h after reperfusion. Results Hyperoxic liquid preconditioning can lower ST segment and improve index of hemodynamics and significantly reduce myocardial infarction size in group C compared with group B((P
