Effects of artesunate on the proliferation and apoptosis of gastric carcinoma cells
- VernacularTitle:青蒿琥酯对人胃癌细胞增殖及凋亡的影响
- Author:
Junning ZHAO
;
Yiran HE
;
Zhenyu ZHANG
- Publication Type:Journal Article
- Keywords:
artesunate;
gastric carcinoma cells MGC-803;
s urvivin gene;
apoptosis
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the roles of artesunate on the proliferation and apoptosis of gastric carcinoma cells,also to explore it s possible mechanism of anticancer effects. Methods:The inhibition on the proliferation of cultured stomach carcinoma cell line(MGC-803) was observed by using MTT analysis.and apo ptosis was assessed by flow cytometry together with transmission electron micros copy.Using reverse transcriptase polymerase chain reaction,the expression of sur vivin mRNA was evaluated before and after action of artesunate on malignant cell s. Results:The proliferation of MGC-803 was inhibited notably by artesunate with a dosage-dependant character(P
