Measurement of serum and urine TGF?1 level in bladder cancer patients and its clinical significance
- VernacularTitle:膀胱癌患者血清、尿液中TGF?1水平测定及临床意义
- Author:
Riqiang ZHANG
- Publication Type:Journal Article
- Keywords:
transitional cell carcinoma;
TGF?1;
serum;
ur ine
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the role of TGF?1 in the occu rrence and development of bladder transitional cell carcinoma. Methods:To quantitatively measure the serum and urine TGF?1 le vel in bladder cancer patients with ELISA technique. Results:The serum TGF?1 level(72.64?14.31 ng/ml) in bladder c ancer patients was significantly higher than that in normal controls(62.07?11.3 6 ng/ml). With the progression in pathological stage, grade and tumor advancemen t, the serum TGF?1 level in patients changed in a decreasing trend. The urine T GF?1 level(803?552 pg/ml) in patients was significantly lower than that in nor mal controls(2995?1891 pg/ml). The differences of urine TGF?1 level in patient s with different pathological stages and grades were not significant. Conclusions:The elevated serum TGF?1 level may be the cause of damaged cellular immune function in bladder cancer patients. The reduction of u rine TGF?1 level in patients could lead to the acceleration of tumor cell proli feration and may be the risk factor for tumor recurrence.
