Role of telomere, telomerase and hTERT in colorectal carcinoma
- VernacularTitle:端粒、端粒酶及端粒酶催化亚基在大肠癌中的作用
- Author:
Jianlun LIU
;
Lianying GE
;
Danrong LI
- Publication Type:Journal Article
- Keywords:
colorectal carcinoma;
telomere;
telomerase;
hT ERT
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To explore the role of terminal restric tion fragments (TRFs), telomerase activity and expression of human telomerase re verse transcriptase (hTERT) in colorectal carcinoma. Methods:The telomere length, telomerase activity and expression of hTERT were studied with Southern-blot, TRAP and immunohistochemistry, respe ctively. Results:TRFs in cancer tissue was much shorter than in the adja cent tissues and normal mucosa, and TRFs was decreased gradually along with the development in cancer stage.The expression of Telomerase in colorectal carcinoma tissue was significantly higher than that in other tissues (P
