Therapeutic effects of 3-dimensional conformal radiotherapy(3D-CRT) and concurrent chemotherapy in advanced non-small-cell lung cancer(NSCLC)
- VernacularTitle:立体适形放疗合并化疗治疗中晚期非小细胞肺癌
- Author:
Dandan YU
;
Ruifeng ZHENG
;
Min YAN
- Publication Type:Journal Article
- Keywords:
radiotherapy;
chemotherapy;
non-small-cell lu ng cancer;
vinorelbine;
cisplatin
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To evaluate the therapeutic effects of 3-D conformal radiotherapy(3D-CRT) and concurrent chemotherapy in advanced non -small-cell lung cancer(NSCLC). Methods:38 stage Ⅲ NSCLC patients were given radio therapy to a total dose of 75~80 Gy(5-10 Gy/fraction;8-10 fractions)by using SCRT.And ea ch patient was given four cycles of concurrent chemotherapy(vinorelbine 25 mg/m ~2 on Days1,8;cisplatin 80 mg/m~2 on Days1;21 days for one cycle). Results:The response rate was 92.1%,of which 16 complete respo nders and 19 partial responders .The survival rate was 74.53%at 1 year, 37.45% at 2 years,the median survival time was 16 months. Conclusions:Stereotactic conformal radiotherapy and concurrent chemotherapy,as described here,is a well tolerated regimen with acceptable toxic ity.More effective treatment schemes are required to improve local disease contr ol and overall survival.
