Rho family expression in neoplasms and its clinical significance
- VernacularTitle:Rho家族在肿瘤组织的表达及临床意义
- Author:
Hao WANG
;
Yuxia CHEN
;
Jian LU
- Publication Type:Journal Article
- Keywords:
Rho family;
neoplasms;
marker
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Rho(Ras homologue) family play an import ant role in intracellular signal-transduction pathways. Not until recently have they been found to overexpress in many kinds of tumors such as testicular germ cell tumor,colorectal tumor,breast cancer,ductal adenocarcinoma of the pancreas and prostate cancer and been linked to the tumorigenesis and metastasis. So the members of the Rho family of small guanosine triphosphatases would be new marker s for tumor diagnosis、new markers for the prediction of metastatic potential an d new important prognostic factors. Moreover,they have the potential as therape utic targets for the prevention of cancer invasion and metastasis. In this artic le, we review the recent progress in this field.
