Studies on HNF-4? and HNF-1? mRNA expressions in livers of type 2 diabetic rats
- VernacularTitle:2型糖尿病大鼠肝脏肝细胞核因子(HNF)-4?、HNF-1?基因表达研究
- Author:
Jing WU
;
Suhua ZHANG
;
Yinxing NI
- Publication Type:Journal Article
- Keywords:
Rats, Wistar;
Hepatocyte nuclear factors;
Gene expression;
Diabetes mellitus,experimental;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of HNF-4? and HNF-1? gene were assayed by RT-PCR in the livers of insulin-resistant rats and type 2 diabetic rats. mRNA levels of HNF-4? and HNF-1? in insulin-resistant rats were lower than those in control rats, and these levels were further decreased in diabetic rats. Changes in expressions of these 2 genes seem to be associated with type 2 diabetes mellitus.
