Immune deficiency dendritic cell loading antigen induce tolerance of islets grafts in xenotransplantation
- VernacularTitle:抗原负载的免疫缺陷树突状细胞诱导异种胰岛移植耐受
- Author:
Gang ZHAO
;
Fang WANG
;
Chunyou WANG
- Publication Type:Journal Article
- Keywords:
Dendritic cell;
Islet transplantation;
Tolerance
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of host derived immune deficient dendritic cell(DC) on immune tolerance in transplantation of xenoislet.Methods:Mature or immune deficient DC were cultured from BALB/c mice and loaded with MHC antigen of Wistar rat. The DC were injected into the diabetes mice through tail venous, then islets of Wistar or SD rats were implanted beneath the capsule of renal after one week. Survival time of grafts was monitored. Mixed lymphocyte culture and Th1/Th2 cytokine were performed.Results:Surviving time of Grafts in normal group was 8.2?1.1 d, and that of mature DC treated group was 6.1?1.1 d(P
