Expression and correlation of eIF4E and c-myc in laryngeal carcinoma
- VernacularTitle:eIF4E与c-myc在喉癌中的表达及相关性研究
- Author:
Bo TENG
;
Kehui LIU
;
Chunshun JIN
;
Ding XIN
;
Yinan XIA
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasms;
Carcinoma;
eIF4E;
c-myc;
Western blot
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression and correlation of eIF4E and c-myc in laryngeal squamous cell carcinoma.Methods:Western blot was applied to examine the expression of eIF4E and c-myc on tumor core,transition core and tumor-free core from 36 laryngeal carcinoma patients.The results were statistically analyzed.Results:The overexpression of eIF4E and c-myc protein levels suggests an increasing tendency from tumor-free core,transition core and tumor core;and shows an significant correlation of eIF4E and c-myc expression.Conclusion:The overexpression of eIF4E and c-myc cause the laryngeal carcinoma cell malignant transformation;the correlation of eIF4E and c-myc may provide a basis for gene therapy of laryngeal carcinoma.
