Investigation of the level of IL-2 and IL-6 in dog renal transplantation after portal venous injection of donor splenocytes
- VernacularTitle:脾细胞门静脉注射后家犬肾移植后IL-2、IL-6变化的研究
- Author:
Ye JIA
;
Hang YUAN
;
Lining MIAO
;
Hua GU
;
Jing SUN
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Immune tolerance;
Cytokine
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the mechanism of immune tolerance induce by protal venous injection of donor spleen cells on the dog model of renal transplantation.Methods:The donor spleen cells were injected through the protal vein during operation,one week later,renal transplantation was performed.IL-2 and IL-6 were studied by method of ELISA.Results:Level of IL-2 and IL-6 in protal venous group and cyclosporin group was higher than that of control group.There were no difference between protal venous group and cyclosporin group.Conclusion:Immune tolerance could be produced by protal venous injection of donor spleen cells.
