Characteristics of Alu Repeats and Their Relationships with Malignant Tumors
- VernacularTitle:Alu重复序列的特性及其与恶性肿瘤的关系
- Author:
Junfeng WANG
;
Zongguang ZHOU
;
Yao CHEN
- Publication Type:Journal Article
- Keywords:
Alu repeats Malignant tumor Homologous recombination Short interspersed element
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the molecular structures and functions of Alu repeats,and its relationships with malignant tumors. Methods Advances in molecular biology and oncology of Alu repeats in recent years had been reviewed. Results Homologous recombination between Alu repeats may result in various genetic exchanges,including duplications, deletions and translocations,cause a series of malignancy alteration by activating some oncogenes. Conclusion Alu repeats as a sort of multifunction regulatory sequences may play an important role during the carcinogenesis and progression of some tumors.
