Research of ultrasound combined with hemorheology on atherosclerosis in rabbits
- VernacularTitle:超声与血液流变学检测兔动脉粥样硬化
- Author:
Litao SUN
;
Jiawei TIAN
;
Na MA
- Publication Type:Journal Article
- Keywords:
Ultrasonograph;
Hemorheology;
Atherosclerosis;
Rabbit
- From:
Chinese Journal of Ultrasonography
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of high-frequency color Doppler ultrasound technique combined with hemorheology in detecting early atherosclerosis and monitoring its progression.Methods Twenty-four white big ear rabbits were divided into two groups randomly.Group A (6 rabbits) was fed normal rabbit chow,while group B (18 rabbits) was fed high cholesterol diet and was divided into three subgroups: B1(6 rabbits) with high cholesterol diet for 4 weeks,B2(6 rabbits) for 8 weeks,B3(6 rabbits) for 12 weeks.Intima-media thickness (IMT),diameter of common carotid artery and hemorheology index were observed dynamically and compared with the findings of histological examination.Results IMT of common carotid artery increased gradually in group B at different phases of atherosclerosis.Diameter compensationally enlarged at the early stage,and then stenosed with the progression of atherosclerosis.RBC deformation index of group B began reducing in the second week,but blood viscosity,plasma viscosity,RBC aggregation index and rigidity index gradually increased from the fourth week( P
