Tumor necrosis factor ?-308 alleles in myasthenia gravis
- VernacularTitle:重症肌无力患者肿瘤坏死因子等位基因?-308多态性分析
- Author:
Yuzhou GUAN
;
Liying CUI
;
Shangzhi HUANG
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Tumor necrosis factor;
Alleles;
Polymorphism(genetics)
- From:
Chinese Journal of Neurology
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the associations between alleles of TNF?-308 and myasthenia gravis(MG) and its subgroups. Methods A biallelic polymorphism at position -308 in the promoter region of TNF? was screened by polymerase chain reaction (PCR) amplification and NcoⅠ restricted enzyme. One hundred MG patients and one hundred healthy controls of Chinese were analysed. Results The allele TNF?2(A) was found significantly increased in all patients (0.32 in MG vs 0.21 in healthy controls, P0.05), showing a trend of increase in patients with an late onset of disease (0.34) compared to age matched healthy controls (0.10, P
