Clinical value of vascular endothelial growth factor in the diagnosis and treatment of common malignant tumors
- VernacularTitle:血管内皮生长因子在常见恶性肿瘤诊治中的临床价值
- Author:
Fengshou JIANG
;
Yubei SUN
;
Bing HU
- Publication Type:Journal Article
- Keywords:
neoplasms;
vascular endothelial growth factor;
tumor marker;
serodiagnosis;
CEA;
CA50;
CA199;
AFP
- From:China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To explore the clinical significance of VEGF in the diagnosis, treatment and prognosis of common malignant tumors. Methods:The levels of serum VEGF were measured by sandwich enzyme linked immunosorbent assay (ELISA) in 544 patients with malignant tumors and 87 healthy subjects. At the same time,another 6 tumor markers including CEA and CA50 were measured by immunoradiometric assay (IRMA) in 544 malignant tumor patients. Sensitivity, specificity, positive predictive value and negative predictive value of VEGF detection were calculated respectively. The relationship between the pre-treatment levels of serum VEGF and their clinical effect, and between the positive expression number of five kinds tumor markers jointly and the therapeutic effect were analyzed respectively. Results:1. The serum VEGF levels in patients with all kinds of malignant tumors were higher than those of the controls, the mean serum VEGF were relatively higher in patients with gastric cancer, liver cancer and lung cancer. 2. According to the cutoff of medicine reference of VEGF (200.6ng/L), its sensitivity and specificity were 54.2% and 95.4% respectively. There was a significant difference between the sensitivity of serum VEGF in patients with tumor burden (74.9%) and that in patients without tumor burden (20.4%)(P
