Induction of apoptosis in human cholangiocarcinoma cell line QBC939 by taxol in vitro
- VernacularTitle:体外观察紫杉醇对人胆管癌细胞QBC939凋亡的诱导作用
- Author:
Wenhong WU
;
Guangzhe WANG
- Publication Type:Journal Article
- Keywords:
taxol(paclitaxel);
human cholangiocarcinoma cell line;
apoptosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of taxol on QBC939 and its mechanism. Methods The cell proliferation was assessed by MTT assays; cell cycle kinetics and apoptosis were analyzed by flow cytometry and microscopic examination. Results Taxol inhibited the cell growth in concentration and time-dependent manners. The cell showed S and G2/M arrest and apoptosis. Conclusion Taxol suppresses the growth of QBC939 cells in vitro by causing cell-cycle arrest, and apoptosis of the cells.The mechanisms of taxol will provide theoretical guidance for clinical treatment.
