Experimental study on role of endogenous endothelin in echocardiographic evaluation of flow-dependent epicardial coronary vasodilation induced by reactive hyperemia after blockade of nitric oxide formation
- VernacularTitle:抑制一氧化氮合成后内皮素在冠状动脉反应性充血扩张中的作用的实验研究
- Author:
Tianliang LI
;
Youbin DENG
;
Lin WANG
;
Haoyi YANG
;
Qingyang ZHANG
;
Xiaojun BI
;
Huijuan XIANG
;
Jinghua LIU
;
Chunlei LI
;
Qing CHANG
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Coronary vessels;
Endothelin;
Nitric oxide
- From:
Chinese Journal of Ultrasonography
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether endogenous endothelin(ET) plays a role in the echocardiographic evaluation of the flow-dependent epicardial coronary vasodilation induced by reactive hyperemia(RH) after blockade of nitric oxide(NO) formation. Methods In six anesthetized open-chest dogs, changes in internal diameter of the left anterior descending coronary artery(LAD) induced by RH were investigated via echocardiography before intracoronary infusion of GN-nitro-L-arginine methyl ester(L-NAME), after blockade of NO formation by L-NAME, and after L-NAME plus intracoronary infusion of BQ-123, an ETA receptor blocker.Results Before intracoronary infusion of L-NAME, the diameter of LAD increased significantly from((2.24)?(0.21))mm to ((2.51)?(0.23))mm (P
