In vitro effects of sonodynamic management on inhibition of ovarian cancer cells
- VernacularTitle:声动力效应抑制卵巢癌细胞的体外实验
- Author:
Yanci CHE
;
Qingzhao FU
;
Xiuguo ZHANG
;
Daoxin MA
;
Junsui BAI
- Publication Type:Journal Article
- Keywords:
Ultrasonic therapy;
Ovarian neoplasms;
Hematoporphyrins
- From:
Chinese Journal of Ultrasonography
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the in vitro effects of sonodynamic management on human ovarian cancer cell line HRA. Methods Hematoporphyrin was selected as a sonosensitizer and ultrasound with certain intensity was used to activate hematoporphyrin.Then MTT assay and clony-forming efficiency assay were applied to determine the growth inhibitory effects of ovarian cancer cells. Electron microscope was applied to detect the morphological changes of the cells. Cell apoptosis was analyzed using flow cytometry. Results Hematoporphyrin had no significant inhibitory effects on the cells. However, when hematoporphyrin was used before ultrasound,it could enhance the killing effects of ultrasound(P
