Expression of survivin and vascular endothelial growth factor in thyroid carcinoma and its significance
- VernacularTitle:存活素与血管内皮生长因子在甲状腺癌中的表达及其意义
- Author:
Haiyan ZHANG
;
Daxin GAO
;
Binhong WEN
;
Guoliang LIU
- Publication Type:Journal Article
- Keywords:
Thyroid carcinoma;
Survivin;
Apoptosis;
Vascular endothelial growth factors;
Angiogenesis
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of survivin (an apoptosis inhibitor) in thyroid carcinoma and its relationship with vascular endothelial growth factor (VEGF) expression. Methods Sixty-eight cases of thyroid carcinoma, 12 cases of thyroid adenoma and 10 cases of normal thyroid tissue were involved. Immunohistochemistry (SABC method) was used to detect the expression of survivin, caspase-3 and VEGF, and then their relationship with the major clinicalpathologicalparametersofthyroidcarcinoma was analysed. Results No survivin was expressedinnormalthyroidtissue,butsurvivinwasweakly expressed in thyroid adenoma (16.7%) and strongly expressed in thyroid carcinoma (57.4%); caspase-3 was obviously expressed in three kinds of tissue (70.0%, 75.0%, 69.1%), and VEGF was expressed in 75.0% of thyroid carcinoma and 41.7% of thyroid adenoma. In thyroid carcinoma, survivin expression had no correlation with caspase-3 expression, but significant positive correlation existed between surviving and VEGF (r=0.302,P
