cDNA microarray screening biomarkers which simultaneously participate in different carcinogenesis progression in lung adenocarcinoma
- VernacularTitle:基因芯片筛选同时参与肺腺癌不同癌变进程的分子靶标
- Author:
Jiaying LIN
;
Xuening YANG
;
Jinji YANG
;
Riqiang LIAO
;
Yilong WU
- Publication Type:Journal Article
- Keywords:
Lung neoplasm;
Gene expression;
Microarray
- From:
Cancer Research and Clinic
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the genes which simultaneously participate in different carcinogenesis progression in lung adenocarcinoma for biomarkers identification. Methods 10 lung adenocarcinoma samples including pathologic stage Ⅰ,Ⅱ,Ⅲ were chosen for experiment and their matched normal tissues for control. After hybridization on 20 slides of microarray with 13824 genes, we analyze the expression profiles combined with pathologic stage and clinical prognosis by data mining. The genes differentially coexpressed in different stage and different prognosis samples were the target. Results 119 genes were identified. Among these targets, 26 genes have known to be related to lung cancer, 46 genes were unreported and 47 gene were new. Conclusions The 119 genes were very important during cancer occurrence and development and were the candidate biomarkers in lung adenocarcinoma.
