Study on the expression and clinical significance of p53 and bcl-2 in different cutaneous tumors
- VernacularTitle:bcl-2、p53在皮肤肿瘤中的表达及意义
- Author:
Song ZHAO
;
Huijun DUAN
;
Fengying QI
;
Yingmin LI
- Publication Type:Journal Article
- Keywords:
Skin neoplasm;
bcl-2;
p53;
Flow Cytometry
- From:
Cancer Research and Clinic
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of the expression of p53 and bcl- 2 in different cutaneous tumors. Methods The expression of p53 and bcl- 2 were quantitatively detected by Flow Cytometry(FCM) and immunofluorescence in 10 cases of normal skin, 20 cases of squamous cell carcinoma(SCC), 22 cases of basal cell carcinoma(BCC), 18 cases of malignant melanoma(MM) and 18 cases of pigmented nevus (PN). Fluorescence Index(FI) was defined as the expression index of bcl- 2 and p53 protein. Results The FI for bcl- 2 in SCC and BCC was higher than that in normal skin tissues(P
