Inhibiting effect of HLA-derived peptide on immune function of rat splenocytes
- VernacularTitle:一种新型HLA衍生肽对大鼠脾细胞免疫功能的抑制作用
- Author:
Shanhong YI
;
Zehou WANG
;
Bo SONG
;
Gang YE
- Publication Type:Journal Article
- Keywords:
HLA-derived peptide;
Mixed leukocyte reaction;
Heme oxygenase-1
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the immunosuppression function of a novel HLA-derived pepride, RDP1258,and it' s mechanisms. Methods:A peptide derived from HLA,RDP1258,was chemically synthesized.The effects of the peptide on alloreactive cytotoxic activities of rat splenocytes were observed using 3H-TdR method.The heme oxygenase-1(HO-1) activity was analyzed by the enzyme chemistry method.Results:The results showed that the synthetic HLA-derived peptide can obviusly inhibit the proliferation of rat splenocytes and the peptide inhibited HO-1 activty in a dose-dependment manner in vitro.Conclusion:HO-1 might participate in the RDP1258 inhibiting the proliferation of rat splenocytes induced by mitogen and isoantigen.
