Effect of Qingxin capsule on differentiation of Th cell in the course of viral myocarditis
- VernacularTitle:清心胶囊对病毒性心肌炎不同分期Th细胞分化的影响
- Author:
Qiang LIU
;
Zhiqing CHENG
;
Wu YE
;
Hangping YAO
- Publication Type:Journal Article
- Keywords:
Myocarditis;
Coxsackie virus B;
Mouse;
Differentiation of Th cell;
Cytokine;
Qingxin capsule
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of Th cell differentiation in the VMC and interference effect of Qingxin capsule on them.Methods:BALB/c mouses with different courses of VMC were established, after treated with Qingxin capsule, the cardiac pathological changes were observed by light microscope and transmisson electron microscope,levels of IL-2,IL-4,IL-10 and IFN-? in blood serum were detected by ELISA.Results: Whatever in acute stage or recovery stage of VMC, the myocard pathological changes of mouses were lighter after treated with Qingxin capsule;moreover, levels of IFN-? and IL-2 in blood serum of mouses with VMC decreased significantly(P0.05).Conclusion:Qingxin capsule can restore the balance of Th1 and Th2 cells through inhibiting reaction of Th1 and enhancing reaction of Th2.
